| MODEL-ASSISTED OPTIMIZATION: A CASE STUDY A. Minkov and N. Dimov* NIHFI - Sofia, 3 Kl. Okhridsky str., Sofia, Bulgaria
SUMMARY An experimental mathematical model has been developed for calculation of the retention time of chlorthalidon and clonidine hydrochloride in tablets. Because the maximum error is less than 30 s it is always possible to place the peaks of the target compounds in the specified retention windows. This approach is preferred to the conditions given in Pharmacopoeia 23, because of easier performance.
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